Agitoxin-2 

Blocker of K_v1.1 and K_v1.3 channels

钾离子通道K_v1.1 和K_v1.3阻断剂

Agitoxin-2 is a potent and selective blocker of the Shaker type voltage-gated K_v1.3 and K_v1.1 channels. Agitoxin-2 inhibits K_v1.3 with an IC₅₀ value of around 200 pM and K_v1.1 with an IC₅₀ value of around 140 pM. This peptide toxin was originally isolated from the venom of the Israeli scorpion L. quinquestriatus hebraeus.

Agitoxin-2 技术资料

氨基酸序列：

 Gly-Val-Pro-Ile-Asn-Val-Ser-Cys⁸-Thr-Gly-Ser-Pro-Gln-Cys¹⁴-Ile-Lys-Pro-Cys¹⁸-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys²⁸-Met-Asn-Arg-Lys-Cys³³-His-Cys³⁵-Thr-Pro-Lys-OH

二硫键：Cys⁸-Cys²⁸; Cys¹⁴-Cys³³; Cys¹⁸-Cys³⁵ 

长度 (aa)：  38

分子式： C₁₆₉H₂₇₈N₅₄O₄₈S₈ 

分子量：4090.89 Da

外观： White lyophilized solid

可溶性：water and saline buffer

CAS 号： 168147-41-9

来源： Synthetic 

纯度： > 97 %

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